
General Description
NANOACTIV VB5, also known as D-Panthenol or Provitamin B5, is a highly effective moisturizing and conditioning agent widely used in the cosmetic and personal care industry. It is the alcohol analog of pantothenic acid (Vitamin B5) and plays a vital role in maintaining healthy skin and hair. Renowned for its humectant properties, NANOACTIV VB5 attracts and retains moisture, improving softness, elasticity, and overall texture. It penetrates deeply into the skin and hair shafts, providing long-lasting hydration and nourishment. This ingredient is available in high-purity cosmetic-grade form, suitable for a wide range of formulations.
Uses in the Cosmetics Industry
- NANOACTIV VB5 is a versatile ingredient used across skincare, haircare, and body care formulations for its excellent moisturizing, soothing, and conditioning properties. Typical applications include:
- Facial Creams & Serums: Deeply hydrates and soothes the skin, enhancing suppleness and smoothness.
- Shampoos & Conditioners: Strengthens hair fibers, reduces split ends, and imparts natural shine.
Body Lotions & Hand Creams: Restores softness and elasticity, preventing dryness and roughness. - After-Sun & After-Shave Products: Provides soothing relief and aids in skin recovery.
- Baby Care & Sensitive Skin Products:Gentle and non-irritating, making it ideal for delicate skin types.
- Cosmetic manufacturers commonly buy NANOACTIV VB5 in bulk to enhance the moisturizing and reparative performance of formulations.
- It is compatible with a wide range of active ingredients and works synergistically with emollients, humectants, and vitamins.
Hazards
- NANOACTIV VB5 is considered a safe and non-toxic cosmetic ingredient when used within recommended concentrations. However, as with all actives, certain precautions should be observed:
- Skin Irritation: Very rare; may occur in individuals with extremely sensitive skin if used in excessive concentrations.
- Eye Irritation: Direct contact with the eyes may cause mild, temporary discomfort; formulations should avoid direct eye exposure.
- Stability: Sensitive to heat and strong oxidizing agents; should be stored in a cool, dry place to prevent degradation.
- Inhalation: In powder form (if applicable), prolonged inhalation of dust should be avoided during bulk handling.
Storage & Stability
- Storage Conditions: Store tightly sealed in a cool, dry environment away from direct sunlight and heat sources.
- Shelf Life: Stable under normal storage conditions; maintain below 40°C for optimal longevity.
- Compatibility: Compatible with most emulsifiers, surfactants, and actives commonly used in cosmetic formulations.
- NANOACTIV VB5 is available for bulk and wholesale purchase for manufacturers seeking a high-performance moisturizing and conditioning ingredient that supports skin and hair health.
- Its proven efficacy, safety profile, and versatility make it a premium choice for advanced cosmetic and personal care formulations.
CAS Number: 81-13-0
INCI: Panthenol
Composition:NANOACTIV VB5 is composed of D-Panthenol, the dextrorotatory isomer of panthenol (provitamin B5). It is a biologically active alcohol analog of pantothenic acid, known for its moisturizing, soothing, and repairing properties in cosmetic and personal care formulations.
Purity Grade: Cosmetic / Pharmaceutical Grade (≥ 98%)
Appearance: Clear, colorless to slightly viscous liquid with mild characteristic odor
Solubility:Freely soluble in water, alcohol, and propylene glycol; slightly soluble in ether and chloroform
Preservation:Self-stable; does not require preservatives in raw form. Formulations containing NANOACTIV VB5 should be preserved according to product composition.
Raw Material Sources:Synthetic origin, derived from petrochemical or plant-based intermediates such as isobutyraldehyde and formaldehyde
Manufacture:Produced via a multi-step synthesis involving condensation and hydrogenation reactions to form D-Panthenol, followed by purification to cosmetic or pharmaceutical standards.
Animal Testing: Not animal tested
GMO: GMO-free (synthetic, not derived from genetically modified organisms)
Vegan: Does not contain animal-derived ingredients
Proposition:NANOACTIV VB5 complies with EU Cosmetic Regulation (EC) No. 1223/2009, U.S. FDA cosmetic ingredient standards, and other international regulatory frameworks.
Warning:For external use only. Avoid contact with eyes. Store in tightly closed containers in a cool, dry place away from direct sunlight. Use clean and dry utensils when transferring to prevent contamination.
THE STORY OF NANOACTIV VB5
Nanoactiv VB5: The Pro-Vitamin B5 for Deep Moisture & Repair
Nanoactiv VB5, also known as Pro-Vitamin B5, is a powerful moisturizing and repairing ingredient widely used in skincare, haircare, and personal-care formulations. It helps restore the skin barrier, improve hydration, and promote healing— leaving skin soft and hair smooth, shiny, and strong.
The Active Form of Vitamin B5 – A Biocompatible Humectant
Nanoactiv VB5 is the biologically active enantiomer of Panthenol, the alcohol analog of pantothenic acid (Vitamin B5).
Once absorbed by the skin or hair, it is converted into pantothenic acid, a key component of Coenzyme A, which supports cellular repair and regeneration.
TRCkem supplies high-purity D-Panthenol (≥98%)in liquid or powder form, suitable for both leave-on and rinse-off cosmetics.
Moisturize. Heal. Strengthen.
Nanoactiv VB5 delivers multi-functional benefits across beauty and personal care:
✅ Deep hydration & moisture retention for long-lasting softness
✅ Enhances skin elasticity and promotes barrier repair
✅ Soothes irritation and redness — perfect for sensitive skin
✅ Improves hair strength, shine & manageability
✅ Adds a luxurious feel to lotions and serums
Commonly used in: facial creams, after-sun gels, baby care, shampoos, conditioners, serums, and healing ointments.
Highly Stable, Safe & Globally Approved Pro-Vitamin
• Typical use level: 0.5–5% in skin & hair formulations
• Soluble in water, alcohols, and glycols — easy to add to aqueous phase
• Stable across pH 4–7 and under moderate heat (avoid prolonged >70°C)
• Non-irritating, non-toxic, and ECOCERT / COSMOS approved
• Suitable for sensitive skin and baby care formulations
• Store sealed, in a cool, dry place away from light
• Approved globally (EU, US, ASEAN, India, Japan) for cosmetic & dermal applications
Formulator’s Queries, We Answered
1) What is NanoActiv VB5?
NanoActiv VB5 is a nano-enabled formulation of panthenol (pro-vitamin B₅) created for use in skincare, haircare and scalp products. It delivers the same active molecule (panthenol / provitamin B₅) in a nano-stabilized format intended to improve dispersion, sensory feel and compatibility in modern personal-care systems
2) What is panthenol and why is it used in cosmetics?
Panthenol (pantothenol, provitamin B₅) is a widely used humectant and skin-/hair-conditioning ingredient. It helps hydrate and soothe skin, support skin-barrier repair, improve hair gloss and manageability, and is generally well tolerated in topical use.
3) What are the CAS number and INCI name?
CAS number (D-Panthenol): commonly reported as 81-13-0 for the dextrorotatory (D) form; 16485-10-2 is used for some panthenol / dl-panthenol listings.
INCI name: Panthenol (INCI is used for formulation labelling).
4) What benefits should formulators expect from NanoActiv VB5?
Improved moisturization and skin softness (typical panthenol effect).
Enhanced hair manageability, shine and reduced brittleness when used in hair products.
NanoActiv VB5 is designed to offer easier dispersion and a refined sensory (lighter feel, improved spreadability) compared with some conventional panthenol grades — resulting in smoother, more homogeneous formulations. (Specific performance vs. standard grades depends on formulation and should be verified in finished-product testing.)
5) Typical usage levels / recommended concentrations
Typical use levels for panthenol in personal-care products range from 0.1% up to 5%, depending on the application:
- Leave-on skin and hair serums: 0.5–5%
- Rinsed hair treatments & shampoos: 0.1–1%
- Always perform stability and efficacy testing for your specific formulation.