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LIQ-TRC-DMI-500G

Dimethyl Isosorbide

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SIZE: 500g
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Dimethyl Isosorbide is a high-purity solvent and carrier that enhances the delivery and stability of active ingredients in skincare, promoting deeper penetration and improved formulation performance.

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  • Description

General Description

Dimethyl Isosorbide (DMI) is a clear, colorless liquid derived from isosorbide, which itself is a sugar-based compound usually obtained from glucose or sorbitol. DMI is a high-purity, water-miscible solvent known for its low toxicity, excellent stability, and ability to enhance the delivery of active ingredients through the skin. Chemically, it is a dimethyl ether derivative of isosorbide.

Dimethyl Isosorbide
C8H14O4
5306-85-4
Miscible with water and many organic solvents

Uses in the Cosmetic Industry

Dimethyl Isosorbide is widely used in personal care and cosmetic formulations due to its solvent, carrier, and penetration-enhancing properties.

Hazards and Safety

Dimethyl Isosorbide is considered low hazard, but still requires attention in formulation and handling:

  • Irritation Potential: Generally well-tolerated, though may cause mild skin or eye irritation in some individuals at high concentrations.
  • Toxicity: Low systemic toxicity. Not classified as a carcinogen, mutagen, or reproductive toxin.
  • Inhalation Risk: Minimal under normal use; not volatile at room temperature.
    Safe Use Concentration:Typically used at 1–10% in cosmetic formulations.
  • DETAILS

CAS Number: 5306-85-4

INCI Name: Dimethyl Isosorbide

Composition: Pure compound — Dimethyl ether of isosorbide (a derivative of sorbitol)

Purity Grade: Cosmetic/Pharmaceutical Grade

Appearance: Clear, colorless liquid

Solubility: Miscible with water, alcohols, glycols, and many organic solvents.

Preservation: Generally does not require preservation (it is self-preserving due to low water activity); however, products containing Dimethyl Isosorbide may be preserved according to the full formulation needs.

Storage: Store in a tightly closed container, in a cool, dry, and well-ventilated area; protect from light and moisture

Raw Material Sources: Derived from sorbitol (which is plant-based, typically from corn or wheat) via chemical modification

Manufacture: Synthesized by methylation of isosorbide (itself obtained by dehydration of sorbitol)

Animal Testing: May vary by supplier; confirm with specific manufacturer (many modern suppliers are cruelty-free)

GMO: Non-GMO (when sourced from non-GMO plant materials)

Vegan: Yes, typically considered vegan — synthetic derivative without animal-derived ingredients

Warning:
Avoid ingestion and excessive inhalation of vapors.

THE STORY OF DIMETHYL ISOSORBIDE

Dimethyl Isosorbide: The High-Performance Delivery Solvent for Modern Cosmetics

Dimethyl Isosorbide (DMI) is an advanced solvent and penetration enhancer widely used in skincare, haircare, and pharmaceutical formulations. Known for its ability to deliver actives deeper and more efficiently, DMI improves the performance of ingredients like retinol, salicylic acid, glycolic acid, niacinamide, ferulic acid, and peptides — making formulations more effective and stable.

Eco-Derived Dimethyl Glucose Ester Engineered for Efficient Delivery

Dimethyl Isosorbide is synthesized from isosorbide, a renewable sugar-derived molecule obtained from sorbitol (corn/cane sugar).
Its molecular structure allows it to:
• Dissolve poorly soluble actives
• Enhance stability of sensitive ingredients
• Improve dermal penetration without irritation
TRCkem supplies cosmetic- and pharmaceutical-grade DMI with high purity for advanced formulations.

Boost. Deliver. Stabilize.

Key functional benefits:
✅ Enhances dermal penetration of active ingredients
✅ Boosts performance of acids (AHA/BHA) & retinoids
✅ Stabilizes volatile/oxidation-prone actives
✅ Improves solubility of poorly soluble compounds
✅ Reduces irritation by enabling lower dosage of strong actives

Used in: retinol serums, brightening boosters, exfoliating solutions, anti-aging creams, transdermal patches, scalp serums, and clear gel systems.

Safe, Stable & Versatile — Ideal for High-Active Formulations

• Typical use level: 1–10% (up to 20% for high-active systems)
• Mixable with water, alcohols, glycols, and many oils
• Ideal for serums, gels, hair tonics, and chemical exfoliants
• Enhances stability of actives like:
– Retinol, Resveratrol
– Salicylic Acid / Lactic Acid
– Vitamin C Esters
• Low irritation, non-sensitizing, and globally approved
• Store in cool, dry conditions — highly stable & non-reactive

Formulator’s Queries, We Answered


Dimethyl Isosorbide (DMI) is a highly pure, clear, and stable solvent derived from sorbitol (a sugar alcohol). It is widely used in the personal care and cosmetic industry as a carrier agent to enhance the delivery and penetration of active ingredients into the skin.

CAS Number: 5306-85-4
INCI Name: Dimethyl Isosorbide

Enhanced delivery: Improves the absorption and bioavailability of active ingredients like vitamins, peptides, and botanical extracts.
Solubilization: Helps dissolve poorly soluble ingredients, making formulations more stable.
Stability booster: Enhances the chemical stability of sensitive actives.
Skin feel improvement: Provides a light, non-greasy, and pleasant sensory profile.

Dimethyl Isosorbide is used in a wide range of products, including:
Anti-aging creams and serums
Acne treatments
Skin-brightening products
Scalp and hair care solutions
Sunscreens
Body lotions


Yes, when used within recommended concentrations, Dimethyl Isosorbide is considered safe for cosmetic and personal care applications. It is generally non-irritating, non-sensitizing, and approved for topical use by various regulatory authorities. However, formulators should always ensure it is used according to safety guidelines.


In personal care products, Dimethyl Isosorbide is typically used at concentrations between 1% and 10%, depending on the product type and the active ingredients being delivered.


Dimethyl Isosorbide is derived from sorbitol (originating from natural sources like corn), making it a viable option for brands seeking naturally derived or "clean beauty" compliant ingredients, depending on the full formulation and certification requirements.


Dimethyl Isosorbide typically has a shelf life of up to 24 months when stored properly. It should be kept in a cool, dry place, away from direct sunlight and tightly sealed to avoid contamination.