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SKU:LIQ-AMM-03

Ammonium Thioglycolate

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SIZE: 500g
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Ammonium Thioglycolate is a chemical used in hair treatments to break disulfide bonds, allowing hair reshaping. It's key in perms and relaxers for curl restructuring or straightening.

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General Description:

Ammonium Thioglycolate is a colorless to pale yellow liquid with a distinct, sulfur-like odor. It is the ammonium salt of thioglycolic acid and functions primarily as a reducing agent. Known for breaking disulfide bonds in keratin, it is widely used in hair restructuring applications. Its chemical action is reversible, allowing it to reshape hair fibers when neutralized.

Uses in the Cosmetic Industry:

Used to break and reform disulfide bonds in hair, allowing the hair to be restructured into curls or waves.
Used to chemically relax curly or frizzy hair by breaking keratin bonds and straightening hair fibers.
Occasionally used in formulations for chemical hair removal due to its ability to weaken hair structure.
Found in salon-grade treatments designed to modify hair texture temporarily or semi-permanently.

Hazards:

Can cause moderate to severe irritation to the skin, eyes, and respiratory tract. Protective measures must be taken during formulation and application.
At high concentrations or prolonged exposure, it can damage skin or mucous membranes.
Harmful if swallowed—strictly for external use only in regulated concentrations.
Strong sulfur-like odor may be unpleasant or irritating to some users.
Use is subject to strict concentration limits in most jurisdictions. For example, the EU Cosmetic Regulation allows up to 8% in ready-for-use hair waving products and 11% in depilatories, with required safety warnings and pH control.

CAS Number: 5421-46-5

INCI Name: Ammonium Thioglycolat.

Composition: Ammonium salt of thioglycolic acid
Typically supplied as an aqueous solution (with 40–60% water)
Active component: HSCH₂COONH₄

Purity Grade: Cosmetic Grade / Technical Grade
Standard purity of ≥98% (as active content, depending on supplier)
Often sold as a 50% aqueous solution

Appearance: Clear, colorless to pale yellow liquid
Characteristic sulfurous odor

Solubility: Fully soluble in water
Not soluble in oils or non-polar solvents

Preservation: Does not require added preservatives
Stable under controlled pH and temperature
Antioxidants may be used to enhance stability in complex formulations

Storage: Store in a cool, dry, well-ventilated area
Keep in tightly sealed containers, away from heat, light, and incompatible substances (e.g., oxidizers)
Recommended temperature: 5–25°C
Protect from air and moisture to prevent oxidation

Raw Material Sources: Derived synthetically from:
Thioglycolic acid (typically synthesized from chloroacetic acid and sodium hydrogen sulfide)
Neutralized with ammonium hydroxide

Manufacture: Thioglycolic acid is synthesized from a base reaction of chloroacetic acid and hydrogen sulfide.
It is then neutralized with ammonium hydroxide to form Ammonium Thioglycolate.
The solution is filtered, pH-adjusted, and stabilized for cosmetic use.

Animal Testing: Not tested on animals by ethical suppliers
May be eligible for cruelty-free certification if sourced accordingly

GMO: Non-GMO — not derived from genetically modified organisms
No biotechnological processes involved in its manufacture

Vegan: Yes – synthetic and contains no animal-derived ingredients
Suitable for vegan formulations

Proposition 65 (California): Not listed under California Proposition 65
No known carcinogenic or reproductive toxicity under cosmetic-grade compliance

Warning: For external use only
May cause skin and eye irritation
Can release toxic gases (hydrogen sulfide) if mixed improperly
Wear gloves and eye protection when handling in concentrated form
Avoid inhalation of vapors; use adequate ventilation in manufacturing
Keep out of reach of children
pH must be carefully controlled in final formulation (typically 7.0–9.5)

FAQ (Frequently Asked Questions)

Ammonium Thioglycolate** is a key active ingredient used in hair perming (permanent wave systems) and chemical hair relaxers. It breaks disulfide bonds in hair keratin, allowing hair to be reshaped into curls or straightened, depending on the application.

CAS Number: 5421-46-5
INCI Name: Ammonium Thioglycolate

Yes, when used at controlled concentrations and pH levels, it is considered safe and effective for use in professional hair treatments. It must be used according to cosmetic regulatory guidelines, and neutralizers are typically applied afterward to rebalance pH and prevent damage.

Ammonium Thioglycolate is a synthetic chemical compound made by neutralizing thioglycolic acid with ammonium hydroxide. It is not derived from natural sources.

Yes, in its concentrated form, it can cause irritation to the skin, eyes, and respiratory system. Personal protective equipment (PPE) should be used during handling, and it should only be applied by trained professionals in controlled settings.

Yes. It contains no animal-derived ingredients and is considered vegan. It can be cruelty-free depending on the supplier’s policies and certifications regarding animal testing.

You can find Ammonium Thioglycolate in:
Hair perming systems
Chemical hair relaxers
Keratin softening treatments
Some depilatory (hair removal) creams

It should be stored in tightly closed containers, in a cool, dry, and well-ventilated area, away from heat and oxidizing agents. Avoid exposure to direct sunlight or air, as the ingredient can degrade when oxidized.

Use in well-ventilated areas
Avoid mixing with strong acids or oxidizers
Apply a neutralizer post-treatment to stop the chemical action
Follow local cosmetic safety regulations for concentration limits

No, Ammonium Thioglycolate is not currently listed under California Proposition 65 for carcinogenicity or reproductive toxicity when used within regulatory limits.